Emergency obstetric and newborn care: A priority measure to achieve rapid decline in maternal and newborn mortality in sub-Saharan Africa
Abstract
For more than three decades, sub-Saharan Africa has invested heavily in the five WHO pillars of safe motherhood.Governments, development partners, professional associations and civil society organizations have promoted family planning, strengthened antenatal care, expanded skilled birth attendance, improved postnatal care, and, where permitted by law, advocated for safe abortion services. These interventions have undoubtedly contributed to improved maternal and newborn health and have saved countless lives. Yet the region continues to account for approximately 70% of global maternal deaths.The persistence of this unacceptable burden raises an important question: why have these investments not translated into the dramatic reductions in maternal mortality that many had anticipated?The answer possibly lies in a fundamental but often overlooked reality. Pregnancy is inherently unpredictable. Even among women who receive excellent antenatal care, attend all scheduled clinic visits, and are cared for by skilled birth attendants, life-threatening obstetric complications can develop suddenly and without warning. Haemorrhage, eclampsia, obstructed labour, sepsis, uterine rupture, complications of abortion, and severe neonatal asphyxia frequently occur in women previously considered to have low-risk pregnancies. When these emergencies arise, preventive interventions have already reached their limits. At that critical moment, emergency obstetric and newborn care (EmONC) becomes the only intervention capable of preventing death.
1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263.
2. Mancebo G, Sole-Sedeno JM, Fabrego B, Pinto G, Vizoso A, Alvarez M, Sabate-Garcia RA, Miralpeix E. Influence of Age on Treatment and Prognosis in Ovarian Cancer Patients. Cancers (Basel). 2025;17(9).
3. Yamada Y, Mabuchi S, Kawahara N, Kawaguchi R. Prognostic significance of tumor laterality in advanced ovarian cancer. Obstet Gynecol Sci. 2021;64(6):524-531.
4. Charkhchi P, Cybulski C, Gronwald J, Wong FO, Narod SA, Akbari MR. CA125 and Ovarian Cancer: A Comprehensive Review. Cancers (Basel). 2020;12(12).
5. Kiselev IS, Kulakova OG, Boyko AN, Favorova OO. DNA Methylation As an Epigenetic Mechanism in the Development of Multiple Sclerosis. Acta Naturae. 2021;13(2):45-57.
6. Davalos V, Esteller M. Cancer epigenetics in clinical practice. Ca-Cancer J Clin. 2023;73(4):376-424.
7. Gautam P, Gupta S, Sachan M. Comprehensive DNA methylation profiling by MeDIP-NGS identifies potential genes and pathways for epithelial ovarian cancer. J Ovarian Res. 2024;17(1):83.
8. Earp MA, Cunningham JM. DNA methylation changes in epithelial ovarian cancer histotypes. Genomics. 2015;106(6):311-321.
9. Rajanathadurai J, Perumal E, Sindya J. Advances in targeting cancer epigenetics using CRISPR-dCas9 technology: A comprehensive review and future prospects. Funct Integr Genomic. 2024;24(5).
10. Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, Lin D, Wu C. Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets. Signal Transduct Target Ther. 2024;9(1):149.
11. Singh A, Gupta S, Sachan M. Epigenetic Biomarkers in the Management of Ovarian Cancer: Current Prospectives. Front Cell Dev Biol. 2019;7:182.
12. Terp SK, Stoico MP, Dybkaer K, Pedersen IS. Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review. Clin Epigenetics. 2023;15(1).
13. Chagula DB, Rechcinski T, Rudnicka K, Chmiela M. Ankyrins in human health and disease - an update of recent experimental findings. Arch Med Sci. 2020;16(4):715-726.
14. ANKRD23 ankyrin repeat domain 23 [Internet]. 2025. Available from: https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=200539.
15. Colaprico A, Olsen C, Bailey MH, Odom GJ, Terkelsen T, Silva TC, Olsen AV, Cantini L, Zinovyev A, Barillot E, Noushmehr H, Bertoli G, Castiglioni I, Cava C, Bontempi G, Chen XS, Papaleo E. Interpreting pathways to discover cancer driver genes with Moonlight. Nat Commun. 2020;11(1):69.
16. Yin J, Fu W, Dai L, Jiang Z, Liao H, Chen W, Pan L, Zhao J. ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1. Sci Rep. 2017;7(1):4430.
17. Bates M, Mohamed BM, Lewis F, O'Toole S, O'Leary JJ. Biomarkers in high grade serous ovarian cancer. Biochim Biophys Acta Rev Cancer. 2024;1879(6):189224.
18. Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P. Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. Diabetologia. 2018;61(3):641-657.
19. Erdogan OS, Tuncer SB, Kilic S, Odemis DA, Turkcan GK, Celik B, Avsar M, Yazici H. Genome-wide methylation profiles in monozygotic twins with discordance for ovarian carcinoma. Oncol Lett. 2020;20(6):357.
20. Tuncer SB, Erdogan OS, Erciyas SK, Saral MA, Celik B, Odemis DA, Turkcan GK, Yazici H. miRNA expression profile changes in the peripheral blood of monozygotic discordant twins for epithelial ovarian carcinoma: potential new biomarkers for early diagnosis and prognosis of ovarian carcinoma. J Ovarian Res. 2020;13(1):99.
21. Kurdyukov S, Bullock M. DNA Methylation Analysis: Choosing the Right Method. Biology (Basel). 2016;5(1).
22. Bukowski A, Hoyo C, Vielot NA, Graff M, Kosorok MR, Brewster WR, Maguire RL, Murphy SK, Nedjai B, Ladoukakis E, North KE, Smith JS. Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States. BMC Cancer. 2023;23(1):1072.
23. Balakrishnan K, Chen Y, Dong J. Amplification of Hippo Signaling Pathway Genes Is Governed and Implicated in the Serous Subtype-Specific Ovarian Carcino-Genesis. Cancers (Basel). 2024;16(9).
24. Liyanage C, Wathupola A, Muraleetharan S, Perera K, Punyadeera C, Udagama P. Promoter Hypermethylation of Tumor-Suppressor Genes p16(INK4a),RASSF1A,TIMP3, and PCQAP/MED15 in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers. Biomolecules. 2019;9(4).
25. Recillas-Targa F. Cancer Epigenetics: An Overview. Arch Med Res. 2022;53(8):732-740.
26. Koval AP, Blagodatskikh KA, Kushlinskii NE, Shcherbo DS. The Detection of Cancer Epigenetic Traces in Cell-Free DNA. Front Oncol. 2021;11:662094.
27. Sugimoto K, Ito T, Hulbert A, Chen C, Orita H, Maeda M, Moro H, Fukagawa T, Ushijima T, Katai H, Wada R, Sato K, Sakamoto K, Yu W, Considine M, Cope L, Brock MV. DNA methylation genome-wide analysis in remnant and primary gastric cancers. Gastric Cancer. 2019;22(6):1109-1120.
28. Silvestri GA, Mazzone P. A Novel NGS Assay Using cfDNA Methylation for Early Detection of Lung Cancer in a Screen-Eligible Population. J Thorac Oncol. 2024;19(10):S473-S473.
29. Kiri S, Ryba T. Cancer, metastasis, and the epigenome. Mol Cancer. 2024;23(1).
30. Lavoro A, Ricci D, Gattuso G, Longo F, Spoto G, Vitale ACV, Giuliana MC, Falzone L, Libra M, Candido S. Recent advances on gene-related DNA methylation in cancer diagnosis, prognosis, and treatment: a clinical perspective. Clin Epigenetics. 2025;17(1).
31. Mattei AL, Bailly N, Meissner A. DNA methylation: a historical perspective. Trends Genet. 2022;38(7):676-707.
32. Maleknia M, Ahmadirad N, Golab F, Katebi Y, Haj Mohamad Ebrahim Ketabforoush A. DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors. Epigenet Insights. 2023;16:25168657231199893.
33. Zhao G, Jiang R, Shi Y, Gao S, Wang D, Li Z, Zhou Y, Sun J, Wu W, Peng J, Kuang T, Rong Y, Yuan J, Zhu S, Jin G, Wang Y, Lou W. Circulating cell-free DNA methylation-based multi-omics analysis allows early diagnosis of pancreatic ductal adenocarcinoma. Mol Oncol. 2024;18(11):2801-2813.
34. Lee DY, Kang Y, Im NR, Kim B, Kwon TK, Jung KY, Baek SK. Actin-Associated Gene Expression is Associated with Early Regional Metastasis of Tongue Cancer. Laryngoscope. 2021;131(4):813-819.
35. Alexander D, Jhala N, Chatla C, Steinhauer J, Funkhouser E, Coffey CS, Grizzle WE, Manne U. High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomas. Cancer. 2005;103(10):2163-2170.
36. Elliott HR, Burrows K, Min JL, Tillin T, Mason D, Wright J, Santorelli G, Davey Smith G, Lawlor DA, Hughes AD. Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans. Clinical epigenetics. 2022;14(1):130.
37. Galanter JM, Gignoux CR, Oh SS, Torgerson D, Pino-Yanes M, Thakur N, Eng C, Hu D, Huntsman S, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA, Meade K, Serebrisky D, Rodriguez-Cintron W, Kumar R, Rodriguez-Santana JR, Seibold MA, Borrell LN, Burchard EG, Zaitlen N. Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures. Elife. 2017;6.
38. Li S, Tollefsbol TO. DNA methylation methods: Global DNA methylation and methylomic analyses. Methods. 2021;187:28-43.
39. Li N, Zhu X, Nian W, Li Y, Sun Y, Yuan G, Zhang Z, Yang W, Xu J, Lizaso A, Li B, Zhang Z, Wu L, Zhang Y. Blood-based DNA methylation profiling for the detection of ovarian cancer. Gynecol Oncol. 2022;167(2):295-305.
40. Garcia-Ortiz MV, Cano-Ramirez P, Toledano-Fonseca M, Cano MT, Inga-Saavedra E, Rodriguez-Alonso RM, Guil-Luna S, Gomez-Espana MA, Rodriguez-Ariza A, Aranda E. Circulating NPTX2 methylation as a non-invasive biomarker for prognosis and monitoring of metastatic pancreatic cancer. Clin Epigenetics. 2023;15(1):118
Full Text:
PDFReferences
United Nations. Report of the International Conference on Population and Development, Cairo, 5–13 September 1994. New York: United Nations; 1995.
World Health Organization. Sexual and reproductive health and rights. 2026. Accessed March 4, 2026. https://www.who.int/health-topics/sexual-and-reproductive-health-and-rights
WHO Regional Office for Africa. Sexual and Reproductive Health Fact Sheet WHO African Region. World Health Organization; 2020. https://www.afro.who.int/sites/default/files/2020-06/Sexual%20and%20reproductive%20health-%20Fact%20sheet%2028-05-2020.pdf
WHO Regional Office for Africa. Sexual and Reproductive Health in the African Region in 2024: A Summary. 2025. https://files.aho.afro.who.int/afahobckpcontainer/production/files/Sexual_and_Reproductive_Health_Analytical_Brief_2025.pd
El Ansari W, El-Ansari K, Arafa M. Breaking the silence – systematic review of the socio-cultural underpinnings of men’s sexual and reproductive health in Middle East and North Africa (MENA): A handful of taboos? Arab Journal of Urology. 2025;23(1):16-32. doi:10.1080/20905998.2024.2387511
Sidamo NB, Kerbo AA, Gidebo KD, Wado YD. Socio-Ecological Analysis of Barriers to Access and Utilization of Adolescent Sexual and Reproductive Health Services in Sub-Saharan Africa: A Qualitative Systematic Review. Open Access Journal of Contraception. 2023;14(null):103-118. doi:10.2147/OAJC.S411924
United Nations Population Fund (UNFPA). State of World Population Report 2025. New York: UNFPA.
Ekpor E, Brobbey SS, Kumah CY, Akyirem S. Experience of infertility-related stigma in Africa: a systematic review and mixed methods meta-synthesis. Int Health. 2025;17(6):903-913. doi:10.1093/inthealth/ihaf060
Roomaney R, Salie M, Jenkins D, et al. A scoping review of the psychosocial aspects of infertility in African countries. Reprod Health. 2024;21(1):123. doi:10.1186/s12978-024-01858-2
Archetti C. Infertility as Trauma: Understanding the Lived Experience of Involuntary Childlessness. Cult Med Psychiatry. 2024;48(4):940-960. doi:10.1007/s11013-024-09871-7
Sánchez SI, Jones HR, Bogen KW, Lorenz TK. Barriers experienced by emerging adults in discussing their sexuality with parents and health care providers: A mixed-method study. American Journal of Orthopsychiatry. 2023;93(4):335-349. doi:10.1037/ort0000677
Okpalaku CJ, Ogubuike C. Exploring barriers to parent-adolescent sexual-risk communication among adolescents in Port Harcourt Nigeria: Adolescents’ and parents’ perspective. PLOS Global Public Health. 2025;5(1):e0003148. doi:10.1371/journal.pgph.0003148
Division de la population du DAES (ONU). World Population Prospects 2024 Online Edition. Nations Unies, Département des affaires économiques et sociales, Division de la population ; 2024.
Nations Unies. Le potentiel des jeunes, clé du développement durable de l’Afrique. https://www.un.org/ohrlls/news/young-people%E2%80%99s-potential-key-africa%E2%80%99s-sustainable-development
Amanu A, Birhanu Z, Godesso A. Sexual and reproductive health literacy among young people in Sub-Saharan Africa: evidence synthesis and implications. Global health action. 2023;16(1):2279841.
Torres-Cortés B, Leiva L, Canenguez K, Olhaberry M, Méndez E. Shared Components of Worldwide Successful Sexuality Education Interventions for Adolescents: A Systematic Review of Randomized Trials. International Journal of Environmental Research and Public Health. 2023;20(5):4170. doi:10.3390/ijerph20054170
Rodríguez-García A, Botello-Hermosa A, Borrallo-Riego Á, Guerra-Martín MD. Efficacité de l'éducation complète à la sexualité pour réduire les comportements sexuels à risque chez les adolescents : une revue systématique. Sexes. 2025;6(1):6. doi:10.3390/sexes6010006
Tazinya RMA, Hajjar JM, Yaya S. Renforcement des programmes intégrés de services relatifs à la santé et aux droits sexuels et reproductifs et au VIH pour atteindre les objectifs de développement durable 3 et 5 en Afrique. Reprod Health. 2022;19(1):223. doi:10.1186/s12978-022-01535-2.
Refbacks
- There are currently no refbacks.




