Influence of gemcitabine combined with lobaplatin interventional embolization on vaginal flora and biofilm formation in patients with advanced cervical cancer

Dahai Li

Abstract

This study aimed to evaluate the therapeutic effect of Gemcitabine (GEM) combined with Lobaplatin (LOB) interventional embolization in patients with locally advanced cervical cancer. Sixty patients were randomly assigned to a therapy group (30 cases) treated with GEM+LOB interventional embolization and a control group (30 cases) treated with GEM+LOB intravenous drip. The curative effect and changes in vaginal flora and biofilm formation were assessed using bioinformatics methods and ultraviolet spectrophotometry. The therapy group showed significantly better outcomes (P <0.05), with substantial changes in vaginal flora. The proportion of Gardnerella vaginalis (Gv) in the therapy group decreased from 43.51% before treatment to 13.54% after treatment, and the rate of Gv’s cell membrane formation was significantly shortened. However, no significant differences were found in colony content or cell membrane formation delay between the two groups. GEM+LOB interventional embolization not only improved treatment efficacy and survival prognosis in patients with locally advanced cervical cancer but also modulated vaginal microbiota imbalance and inhibited biofilm formation of Gv. These findings provide a new theoretical basis for optimizing clinical treatment strategies for cervical cancer and exploring the relationship between cancer therapy and vaginal microecological balance.

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