Chlamydia Trachomatis infection in infertile men from Cotonou, Benin

Simon Azonbakin, Marius Adjagba, Delali N’bouke, Maria Amoussou, Yannick Goussanou, Jean Paul Dossou, Anatole Laleye

Abstract

Male infertility accounts for 20-30% cases of infertility, and may be due to hormonal, genetic, toxic or infectious factors. Male urogenital infections caused by Chlamydia trachomatis (CT) are potential causes of male infertility. This study determined the prevalence of Chlamydia trachomatis infection among infertile men in Cotonou. The descriptive cross-sectional study used Real time PCR (RT PCR) to detect Chlamydia trachomatis infection on the first urine stream from 90 participants who did sperm analysis for infertility problems between March 2023 and December 2023. The mean age of the patients was 35.31 ± 7.00 years. Most were cases of primary infertility (62.22%), with an average duration of 5 years. The results showed Chlamydia trachomatis genome detection with RT PCR in 3.33% of subjects. Chlamydia trachomatis-positive subjects exhibited leukospermia and low sperm motility. We conclude that Chlamydia trachomatis infection is common and can lead to serious complications, including male infertility. Serological diagnosis lacks specificity and in case of suspected infection, RT-PCR testing is strongly recommended for the detection of CT.

Full Text:

PDF

References

World Health Organization. 2021. WHO Laboratory

Manual for the Examination and Processing of

Human Semen (6th edition). Cambridge University

Press: Cambridge, UK.

Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S

and Stevens GA. National, regional, and global

trends in infertility prevalence since 1990: a

systematic analysis of 277 health surveys. PLoS

Med. 2012; 9(12):2–5.

Agarwal A, Mulgund A, Hamada A and Chyatte MR. A

unique view on male infertility around the globe.

Reprod. Biol. Endocrinol, 2015 ; 13(1): 37.

Frikh M, Benaissa M, Kasouati J, Benlahlou Y, Chokairi O

and Barkiyou M. Prévalence de l´infertilité

masculine dans un hôpital universitaire au Maroc.

Pan Afr Med J. 2021;(38):4–8.

Notter J , Tirri BF, Bally FC, Karoline and Popp A.

Infections sexuellement transmissibles à Chlamydia

trachomatis. swiss Med forum. 2015;(34):705–11.

Schlosser J, Nakib I, Carré-Pigeon F and Staerman F.

Infertilité masculine: définition et physiopathologie.

Annales d'Urologie, 2007 ;41(3) :127-133

Fiadjoe M, Kwasivi M ,Gwet B and Mayenga JM. Prise en

charge chirurgicale de l’infertilité : moyens et

spécificités en Afrique sub saharienne. Reprod Hum

Horm Paris. 2013;(25):59–63.

Hounnasso PP, Avakoudjo JD, Dankoro G, Soumanou AS,

Natchagandé G,Agounkpe M and Toure R. Male

Infertility: Diagnostic and Epidemiological Aspect

Concerning 96 Cases in a Teaching University

Hospital of Cotonou, Benin Republic. Niger J Surg

Res. 2015;16(1):20–22.

Eboigbodin KE . Simultaneous Detection of Chlamydia

trachomatis and Neisseria gonorrhoeae Using Real

Time Multiplex qPCR Assay . In Methods and

Protocols, Methods in Molecular Biology, vol. 2042,

Springer Nature 2019

Kbirou ,Jandou E, Adnane E,Moataz A, Mohammed D,

Debbagh A and R. Aboutai R , Sexologies. 2022 ;

(2) : 117-122

Diop N, Dieng M, Sy M, Gueye MV, Diallo AS, Dieye D

, Ndiade A, Ngom AI ,

Diatta AL, Faye

O.

Contribution to a better analysis of spermatic and

ultrasound testicular parameters in the follow-up of

male infertility at the Histology Embryology

Cytogenetic Laboratory of Cheikh Anta Diop

University (UCAD), 2023 ;107(358) : 100594

Morphologie. 12. Lemkecher T, Dartigues S, Vaysse J, Kulski O, BarraudLange V, Gattegno L and Wolf P. Leucospermie,

stress oxydatif et fertilité masculine: certitudes et

hypothèses. Gynécologie Obs Fertil. 2005;33(1

:2–10

Barry M , Bah MB , Barry MM , Diallo TMO, Bah MD ,

Diallo TO , Kanté D , Cissé D , Bah I, Diallo AB and

Bah OR . Infection à Chlamydiae Trachomatis en

Milieu Uroandrologique à l’Hôpital Ignace Deen :

Fréquence et Retentissement sur la Fertilité. Health

Sci Dis. 2022 ;23(1) : 97-101

Debonnet C. Dépistage du Chlamydia trachomatis en

population infertile : prévalence et spécificités de

l’infection chez des couples consultant dans le

service d’assistance médicale à la procréation du

centre hospitalo-universtaire de Lille.(Thèse de

doctorat). Université de lille en France; 2020

Zhou H, Wu S, Tang X, Zhou G, Yuan G, Li Q , Chen X ,

Xu X, Sun X , Zhu D and Luo Y , Chlamydia

trachomatis infection in the genital tract is associated

with inflammation and hypospermia in the infertile

male of China. Asian J Androl. 2022 ; 24(1):56–61.

Prathiba G and Innocent DJP. Incidence of Chlamydia

trachomatis Infection in Infertile Urban Population. J

ecobiotechnology. 2010;(3):7–11.

López‐Hurtado M, Velazco‐Fernández M, Pedraza

Sánchez M ,Flores‐Salazar, V R Villagrana Zesati

VR and Guerra‐Infante R .Molecular detection of

Chlamydia trachomatis and semen quality of sexual

partners of infertile 2018;(50):128–30. women. Andrologia.

Mazzoli S, Cai T, Addonisio P, Bechi A, Mondaini N and

Bartoletti R. Chlamydia trachomatis infection is

related to poor semen quality in young prostatitis

patients. Eur Urol. 2010;57(4):708–14.

Dupin N, Janier M, Bouscarat F, Vernay-Vaisse C,

Spenatto N, and Vermersch-Langlin A et la section

MST de la SFD. Infection a Chlamydia Trachomatis . Ann

Dermatol 2006;133(Suppl. 8/9):2S1–71. Venereol

Jaton K and Greub G. Chlamydia: signe d’appel

,diagnostic et traitement. Rev Med Suisse.

;(1):895–903.

Berry L and Stanley B. Comparison of self-collected

meatal swabs with urine specimens for the diagnosis

of Chlamydia trachomatis and Neisseria gonorrhoeae

in men. J Microbiol. 2017;(66):134-6.

Legkobyt T and Despeyroux SYL. Diagnostic biologique

de l’infection à Chlamydia trachomatis. Haute

autorité de santé. 2010;(16):10–16.

Refbacks

  • There are currently no refbacks.