This study investigated the effect of acupuncture in patients with poor ovarian response (POR) receiving controlled ovarian stimulation (COS). Sixty seven patients with POR were randomly divided into two groups: Group A (acupuncture+COS) and Group B (COS only). The results showed that the rate of high-quality embryos and rate of available embryos in group A were significantly higher than those in group B (P<0.01). In addition, the number of high-quality embryos in Group A also significantly increased (P<0.05). There was no significant difference in the number of available embryos between the two groups (P>0.05), but group A showed an upward trend compared to group B. Therefore, acupuncture can be considered as a safe and effective method to add to COS in the treatment of patients with POR.

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Ferraretti A. P., La Marca L., Fauser B. C. J. M.,

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Tarlatzis B., Nargund G. and Gianaroli L. ESHRE

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consensus on the definition of poor response' to

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ovarian stimulation for in vitro fertilization: the

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Bologna criteria. Human Reproduction

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;26(7):1616-1624. doi:

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1093/humrep/der049.

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Norman RJ and Hart RJ. Human growth hormone use in

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poor ovarian response - caution and opportunities.

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Ther Adv Reprod Health. 2021 Mar

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Saharkhiz N, Zademodares S, Salehpour S, Hosseini S,

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Nazari L and Tehrani HG. The effect of testosterone

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gel on fertility outcomes in women with a poor

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response in in vitro fertilization cycles: A pilot

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randomized clinical trial. J Res Med Sci. 2018 Jan

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Ubaldi F, Vaiarelli A, D'anna R and Rienzi L.

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Management of poor responders in COS: is there

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anything new? Biomed Res Int 2014;2014:352098.

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doi: 10.1155/2014/352098.

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Jang S, Kim KH, Jun JH and You S. Acupuncture for in

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vitro fertilization in women with poor ovarian

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response: a systematic review. Integr Med Res.

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1016/j.imr.2020.02.003.

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Lin G, Liu X, Cong C, Chen S and Xu L. Clinical efficacy

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of acupuncture for diminished ovarian reserve: a

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systematic review and meta-analysis of randomized

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controlled trials.[J] .Front Endocrinol (Lausanne),

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, 14: 0.doi: 10.3389/fendo.2023.1136121.

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Wang Rong-Rong, Su Meng-Hua, Liu Li-Ying, Li XueFeng, Zhou Xiao-Feng, Zhao Ying, Yang Yun,

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Zhang Xiao-Yun, He Long, Yang Ling-Ling, Wei

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Yu-Ping, Zhang Hong, Wang Ying, Luo Jia and

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Ren Yan-Jiang. Systematic review of acupuncture

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to improve ovarian function in women with poor

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ovarian response. Front Endocrinol (Lausanne)

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Chen Y, Fang Y, Yang J, Yang H, Liu Y, Zeng L, Wang

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L, Zhu S and Zhao Y. Effect of acupuncture on

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premature ovarian failure: a pilot study. Evid Based

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Complement Alternat Med 2014;2014:718675. doi:

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1155/2014/718675.

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Jing L, Wei C, Wei S, Zhang L, Gao L, Xu J, Li L, Huang

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Y, Chen Z, Zhang X, Ma H, Zhu H, Lu W, He J and

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Xu L. Effect of electroacupuncture on oocytes

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quality and tumor necrosis factor-α of patients with

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(mysql): SELECT * FROM metadata_descriptions WHERE assoc_type = 1048579 AND assoc_id = 190802 ORDER BY metadata_description_id DESC  

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polycystic ovarian syndrome. World Journal of

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Acupuncture-Moxibustion (WJAM) 2014;24(3):9-

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doi: 10.4103/1004-3059.138924.

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Kim Jihyun, Lee Hoyoung, Choi Tae-Young, Lim JangSoo, Lee Han-Joo, Choi Ju-Young, Kim MyoungJin, Kwon Yeon-Hee, Lee Jong-Ik, Jang KyoungBok and Choi Eun-Joo. Acupuncture for Poor

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Ovarian Response: A Randomized Controlled Trial.

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Circular of the Ministry of Health on the Revision of

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Technical Specifications, Basic Standards and

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Ethical Principles Related to Assisted Human

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Reproductive Technology and Human Sperm Banks. Bulletin of the Ministry of Health of the

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People's Republic of China 2003(03):1-10.

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assessment of oocytes and embryos at different

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stages of preimplantation development: a review.

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Hum Reprod Update 2003;9(3):251-262. doi:

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1093/humupd/dmg019.

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Smith C A, De Lacey S, Chapman M, Richards S H,

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Cummings T M, White A R, James W, Ireland S,

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Lush D and Duley L. Effect of Acupuncture vs

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Sham Acupuncture on Live Births Among Women

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Undergoing In Vitro Fertilization: A Randomized

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Clinical Trial. JAMA, 2018, 319(19): 1990-1998.

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randomized controlled trials for acupuncture's

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effects on polycystic ovary syndrome or in vitro

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fertilization support. J Integr Med, 2020, 18(2): 89-

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Dehghani A S, Homayouni K, Kanannejad Z, Ahmadi K,

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Mohammadi F, Salehnia M and Najafzadeh F. The

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effect of acupuncture on the day of embryo transfer

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on the in vitro fertilization outcomes: An RCT. Int

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J Reprod Biomed, 2020, 18(3): 209-214. doi:

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18502/ijrm.v18i3.2811.

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Hullender Rubin L E, Anderson B J and Craig L B.

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Acupuncture and in vitro fertilisation research:

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(mysql): SELECT * FROM metadata_descriptions WHERE assoc_type = 1048579 AND assoc_id = 190840 ORDER BY metadata_description_id DESC  

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current and future directions. Acupunct Med, 2018,

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