A Review of the Changes in the Ophthalmic and Visual System in Pregnancy
), Joseph M. Waziri-Erameh(2), Valentina W. Okeigbemen(3),
(1) 
(2) 
(3) 
Corresponding Author
Abstract
Pregnancy is often associated with ocular changes which may be more commonly transient but occasionally, permanent. It may be associated with the development of new ocular conditions, or can exacerbate pre-existing conditions. The ocular effects of pregnancy may be physiological or pathological or may be modifications of pre-existing conditions.Adnexial changes include chloasma, spider angiomas and ptosis. Anterior segment changes include a decrease in conjunctival capillaries and an increase in the granularity of conjunctival venules and in corneal curvature, changes in corneal thickness, refractive index, accommodation and refractive errors, and a decrease in intraocular pressure. Posterior segment changes include worsening of diabetic retinopathy, central serous chorioretinopathy, increased risk of peripheral vitreochorioretinal dystrophies and retinal detachment, and a beneficial effect on non-infectious uveitis. Systemic disorders of importance include preeclampsia, Graves disease and multiple sclerosis. Intracranial disorders with ocular effects in pregnancy include Pseudotumor cerebri, prolactinomas and Sheehan’s syndrome (Afr J Reprod Health 2008; 12[3]:185-196).
RĖSUMĖ
Examen des changements dans la grossesse ophtalmique et du système visuel La grossesse est souvent associée aux changements oculaires qui peuvent être plus généralement la coupure, mais de temps en temps, permanents. Il peut être associé au développement de nouvelles conditions oculaires, ou peut renforcer des conditions préexistantes. Les effets oculaires de grossesse peuvent être physiologiques ou pathologiques ou peuvent être les modifications des conditions préexistantes. Les changements annexais incluent chloasma, des angiomes d'araignée et ptose. Des changements de segment antérieurs incluent une diminution dans des capillaires conjonctivales et une augmentation de la granularité de vénales conjonctivales et dans la déviation cornéenne, des changements de l'épaisseur cornéenne, de l’indice de réfraction, et des erreurs réfractions et une diminution dans la pression intraoculaire. Des changements de segment postérieurs incluent la dégradation de rétinopathie diabétique, choriorétinopathie séreux central, le risque accru du périphérique vitréochoriorétinal des dystrophies et le décollement de la rétine et des effets avantageux sur uvéites non contagieux. Les désordres systémiques d'importance incluent pré éclampsie, la maladie de Tombes et la sclérose en plaques. Des désordres intracrâniens avec des effets oculaires dans la grossesse incluent la Pseudotumeur cérébrale, prolactinomas et le syndrome de Sheehan (Afr J Reprod Health 2008; 12[3]:185196).
KEY WORDS: Pregnancy, Ocular changes, Diabetic retinopathy, Preeclampsia
References
Thornburg, KL, Jacobson SL, Giraud GD, Morton MJ. Hemodynamic changes in pregnancy Semin Perinatol 2000; 24: 11-14
Sunness JS. The pregnant woman’s eye. Surv Ophthalmol 1988; 32: 219-38.
Soubrane G, Canivet J, Coscas G. Influence of pregnancy on the evolution of background retinopathy: preliminary results of a prospective fluorescein angiography study Int Ophthalmol Clin 1985; 8: 249-255
Hellstedt T, Kaaja R, Teramo K, Immonen I. Macular blood flow during pregnancy in patients with early diabetic retinopathy measured by blue-field entoptic simulation Graefes Arch Clin Exp Ophthalmol 1996; 234: 659-663
Loukovaara S, Harju M, Kaaja R, Immonen I. Retinal capillary blood flow in diabetic and nondiabetic women during pregnancy and postpartum period. Invest Ophthalmol Vis Sci 2003; 44:1486-91.
Dinn RB, Harris A, Marcus PS. Ocular changes in pregnancy. Obstet Gynecol Surv 2003; 58:137-44.
Sheth BP, Mieler WF. Ocular complications of pregnancy. Curr Opin Ophthalmol. 2001; 12: 455-63.
Pritchard JA, MacDonald PC, Grant NF. Williams Obstetrics. 17th ed. Norwalk,
Conn. Appleton-Century-Crofts, 1985:18891.
Somani S. Pregnancy, special considerations. www.emedicine.com/oph/topic747.htm.
Schechter JE, Pidgeon M, Chang D, Fong YC, Trousdale MD, Chang N. Potential role of disrupted lacrimal acinar cells in dry eye during pregnancy. Adv Exp Med Biol. 2002; 506:153-7.
Ding C, Chang N, Fong YC, Wang Y, Trousdale MD, Mircheff AK, Schechter JE. Interacting influences of pregnancy and corneal injury on rabbit lacrimal gland immunoarchitecture and function. Invest Ophthalmol Vis Sci. 2006; 47:1368-75.
Park SB, Lindahl KJ, Temnycky GO, Aquavella JV. The effect of pregnancy on corneal curvature. CLAOJ 1992; 18: 256-9.
Pilas-Pomykalska M, Czajkowskii J, Oszukowski P. Ocular changes during pregnancy. Ginekol Pol 2005; 76: 655-60.
Riss B, Riss P. Corneal sensitivity in pregnancy. Ophthalmologica 1981;183: 5762.
Duke-Elder S. System of Ophthalmology. Vol.7. St. Louis: CV Mosby, 1971:703.
Qureshi IA. Intraocular pressure and pregnancy: a comparison between normal and ocular hypertensive subjects. Arch Med Res 1997; 28: 397-400.
Axer-Siegel R, Hod M, Fink-Cohen S,
Kramer M, Weinberger D, Schindel B, Yassur Y. Diabetic retinopathy during pregnancy. Ophthalmology 1996; 103:1815-
Rosenn B, Miodovnik M, Kranias G, Khoury
J, Combs CA, Mimouni F, Siddiqi TA, Lipman MJ. Progression of diabetic retinopathy in pregnancy: association with hypertension in pregnancy. Am J Obstet Gynecol 1992; 166:1214-8.
Temple RC, Aldridge VA, Sampson MJ, Greenwood RH, Heyburn PJ, Glenn A. Impact of pregnancy on the progression of diabetic retinopathy in Type 1 diabetes. Diabet Med 2001; 18: 573-7.
Ayed S, Jeddi A, Daghfous F, el Euch M, Ben Osman N, Marrakchi S, Nacef L. Developmental aspects of diabetic retinopathy during pregnancy. J Fr Ophtalmol 1992; 15:474-7.
Oguz H. Diabetic retinopathy in pregnancy: Effects on the natural course. Semin Ophthalmol 1999; 14:249-57.
Best RM, Chakravarthy U. Diabetic retinopathy in pregnancy. Br J Ophthalmol 1997; 81:249-51.
Sheth BP. Does pregnancy accelerate the rate of progression of diabetic retinopathy? Curr Diab Rep 2002; 2: 327-30.
Soubrane G, Coscas G. Influence of pregnancy on the evolution of diabetic retinopathy. Int Ophthalmol Clin 1998; 38:187-94.
Wender-Ozegowska E, Zawiejska A, Pietryga
M, Zozulinska D, Wierusz-Wysocka B, Chmaj K, Biczysko R. Effect of pregnancy on diabetic vascular complications. Ginekol Pol 2004; 75: 342-51.
Moss SE, Klein R, Klein BE. Ocular factors in the incidence and progression of diabetic retinopathy. Ophthalmology 1994; 101: 7783.
Chan WC, Lim LT, Quinn MJ, Knox FA, McCance D, Best RM. Management and outcome of sight-threatening diabetic retinopathy in pregnancy. Eye 2004;18: 82632.
Sunness JS, Haller JA, Fine SL. Central serous chorioretinopathy and pregnancy. Arch Ophthalmol.1993; 111: 360-4.
Haimovici R, Koh S, Gagnon DR, et al. Risk factors for central serous chorioretinopathy: A case-control study. Ophthalmology
;111: 244-9.
Khairallah M, Nouira F, Gharsallah R, Chachia N. Central serous chorioretinopathy in a pregnant woman. J Fr Ophtalmol 1996; 19: 216-21.
Kolenko OV, Sorokin EL, Egorov VV. Relationship between constitutional type of systemic hemodynamics and formation of peripheral vitreo-chorioretinal dystrophies during pregnancy. Vestn Oftalmol. 2002;118: 20-3.
Landau D, Seelenfreund MH, Tadmor O, Silverstone BZ, Diamant Y. The effect of normal childbirth on eyes with abnormalities predisposing to rhegmatogenous retinal detachment. Graefes Arch Clin Exp
Ophthalmol 1995;233:598-600.
Sinclair SH, Nesler C, Foxman B, et al. Macular edema and pregnancy in insulindependent diabetes. Am J Ophthalmol 1984; 97:154-67.
Kump LI, Cervantes-Castañeda RA, Androudi SN, Foster CS, Christen WG. Patterns of exacerbations of chronic noninfectious uveitis in pregnancy and puerperium. Ocul Immunol Inflamm
;14:99-104.
Taguchi C, Ikeda E, Hikita N, Mochizuki M. A report of two cases suggesting positive influence of pregnancy on uveitis activity. Nippon Ganka Gakkai Zasshi 1999;103:66-
Rabiah PK, Vitale AT. Noninfectious uveitis and pregnancy. Am J Ophthalmol
;136:91-8.
Pleyer U, Torun N, Liesenfeld O. Ocular toxoplasmosis. Ophthalmologe. 2007;104: 603-16.
Bonfioli AA, Orefice F. Toxoplasmosis. Semin Ophthalmol. 2005; 20:129-41
Ouerhani R, Skhiri A, Nefoussi R, Abdellah E, Triki A, Faouzi Gara M. Toxoplasmic infection in pregnancy. Report of 12 cases. Tunis Med. 2006; 84:805-7.
Wallon M, Gaucherand P, Al Kurdi M, Peyron F. Toxoplasma infections in early pregnancy: consequences and management. J Gynecol Obstet Biol Reprod (Paris). 2002; 31:478-84.
Pritchard JA, MacDonald PC, Grant NF. Williams Obstetrics, ed. 17. Norwalk, Conn: Appleton-Century-Crofts, 1985; 525-60.
Prado RS, Figueiredo EL, Magalhaes TV. Retinal detachment in preeclampsia. Arq Bras Cardiol. 2002; 79:183-6.
Somfai GM, Miháltz K, Tulassay E, Rigó J. Diagnosis of serous neuroretinal detachments of the macula in severe preeclamptic patients with optical coherence tomography. Hypertens Pregnancy. 2006; 25:11-20.
Sánchez Vicente JL, Ruiz Aragón J, Nanwani K, Sánchez Vicente P, Guiote Linares JR, Díez Garretas C, Herrador Montiel A. Retinal detachment in preeclampsia and HELLP Syndrome. Arch Soc Esp Oftalmol.
;78:335-8
Waziri-Erameh MJM, Omoti AE, Edema OT. Bilateral total loss of vision following eclampsia-A case report. Afr J Reprod Health. 2003; 7:106-108.
Llovera I, Roit Z, Johnson A, Sherman L. Cortical blindness, a rare complication of pre-eclampsia. J Emerg Med. 2005; 29:295-
Do DV, Rismondo V, Nguyen QD. Reversible cortical blindness in preeclampsia. Am J Ophthalmol. 2002; 134:916-8
Capoor S, Goble RR, Wheatley T, Casswell AG. White-centered retinal hemorrhages as an early sign of preeclampsia. Am J Ophthalmol 1995; 119:804-6.
McLoone EM, Best RM. Pregnancy-related papillophlebitis. Eur J Ophthalmol 2004; 14:65-6.
Beck RW, Gamel JW, Willcourt RJ, Berman G. Acute ischemic optic neuropathy in severe preeclampsia. Am J Ophthalmol 1980;
:342-6.
Saito Y, Tano Y. Retinal pigment epithelial lesions associated with choroidal ischemia in preeclampsia. Retina. 1998; 18:103-8.
Brown RS. Autoimmune thyroid disease in pregnant women and their offspring. Endocr Pract. 1996; 2: 53-61.
Becks GP, Burrow GN. Thyroid disease and pregnancy. Med Clin North Am 1991;
:121-50.
Chan GW, Mandel SJ. Therapy insight: management of Graves' disease during pregnancy. Nat Clin Pract Endocrinol Metab. 2007; 3: 470-8.
Confavreux C, Hutchinson M, Hours M, Cortinovis-Tourniaire P, Grimaud J, Moreau T. Multiple sclerosis and pregnancy: clinical issues. Rev Neurol (Paris). 1999; 155: 18691.
Vukusic S, Confavreux C. Multiple sclerosis and pregnancy. Rev Neurol (Paris). 2006; 162:299-309.
Bernardi S, Grasso MG, Bertollini R, Orzi F, Fieschi C. The influence of pregnancy on relapses in multiple sclerosis: a cohort study. Acta Neurol Scand. 1991; 84:403-6.
Leiba H, Glaser JS, Schatz NJ, Siatkowski RM. Postpartum optic neuritis: etiologic and pathophysiologic considerations. J
Neuroophthalmol. 2000; 20: 85-8.
Retzloff MG, Kobylarz EJ, Eaton C. Optic neuritis with transient total blindness during lactation. Obstet Gynecol. 2001; 98: 902-4.
Bashiri A, Mazor M, Maymon E, Wiznitzer A, Brisko D, Leiberman JR. Pseudotumor cerebri during pregnancy. Harefuah. 1996; 131:397-402, 455.
Peterson CM, Kelly JV. Pseudotumor cerebri in pregnancy. Case reports and review of literature. Obstet Gynecol Surv.
;40:323-9.
Deev AS, Karpikov AV, Pchelintseva ZI. The causes and clinical course of benign intracranial hypertension. Lik Sprava. 1995; 3-4:101-3.
Frohman LA. Pituitary tumors in pregnancy. Endocrinologist 2001;11: 399-406.
Nader S. Thyroid disease and other endocrine disorders in pregnancy. Obstet Gynecol Clin North Am 2004; 31: 257-85.
Krupp P, Monka C. Bromocriptine in pregnancy: Safety aspects. Klin Wochenschr 1987; 65: 823-7.
Kelestimur F. Sheehan's syndrome. Pituitary.
; 6: 181-8.
Article Metrics
Abstract View
: 635 times
Download : 0 times
Refbacks
- There are currently no refbacks.




