Patterns of contraception utilization among reproductive-aged women with thyroid cancer undergoing radioiodine ablation: A study at Hasan Sadikin Hospital

Haidarotul Milla, Mulyanusa A. Ritonga, Hartanto Bayuaji, Erwin Affandi Soeriadi

Abstract

The incidence of new cases of thyroid cancer worldwide is around 10.1/100.000 in woman dan 3.1/100.000 in men. Women with thyroid cancer are advised to avoid pregnancy while undergoing radioablation due to teratogenicity. Therefore, it is crucial to utilize contraception to avoid pregnancy during treatment. The purpose of this study was to determine the characteristics of contraceptive use patterns in women with thyroid cancer of reproductive age who underwent radioablation at Hasan Sadikin Hospital Bandung.Cross-sectional study conducted at Hasan Sadikin Hospital Bandung in May 2023. The research sample was all female thyroid cancer of reproductive age who underwent radioablation at the Nuclear Medicine polyclinic of Dr. Hasan Sadikin Bandung in January-December 2022 by purposive sampling. Data obtained from patient medical records and primary data from patients. A total of 450 patients fulfilled inclusion criteria, but only 329 analyzed with complete data. Majority of the patient was in age group 35-49 years (58.1%), parity >1 (55.9%), last education high school (39.2%), married (81.8%), type of papillary thyroid carcinoma (79.9%), sources of information about contraception from doctors (71.7%), and 75.4% use contraception. The most widely used type of contraception was intrauterine device (IUD), accounting for 28.6% patients. Approximately 75.4% patient use contraception. The most widely used type of contraception is the IUD. Contraception counselling is important for increasing contraceptive use rates among women with thyroid cancer. Further research in the form of analytical research is needed to assess the factors that influence contraceptive use in women with thyroid cancer of reproductive age. (Afr J Reprod Health 2024; 28 [5]: 39-46).

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References

Lee K, Anastasopoulou C, Chandran C and Cassaro S.

Thyroid Cancer. In: StatPearls [Internet]. Treasure

Island (FL): StatPearls Publishing; 2024 [cited 2024

Apr 7]. Available from:

http://www.ncbi.nlm.nih.gov/books/NBK459299/

Pizzato M, Li M, Vignat J, Laversanne M, Singh D, La

Vecchia C, et al. The epidemiological landscape of

thyroid cancer worldwide: GLOBOCAN estimates

for incidence and mortality rates in 2020. Lancet

Diabetes Endocrinol. 2022 Apr;10(4):264–72.

Limaiem F, Rehman A, Anastasopoulou C and Mazzoni T.

Papillary Thyroid Carcinoma. In: StatPearls

[Internet]. Treasure Island (FL): StatPearls

Publishing; 2024 [cited 2024 Apr 7]. Available from:

http://www.ncbi.nlm.nih.gov/books/NBK536943/

Kim HO, Lee K, Lee SM and Seo GH. Association Between

Pregnancy Outcomes and Radioactive Iodine

Treatment After Thyroidectomy Among Women

With Thyroid Cancer. JAMA Intern Med. 2020 Jan

;180(1):54–61.

Singh S and Sandhu S. Thyroid Disease and Pregnancy. In:

StatPearls [Internet]. Treasure Island (FL): StatPearls

Publishing; 2024 [cited 2024 Apr 7]. Available from:

http://www.ncbi.nlm.nih.gov/books/NBK538485/

Springer D, Jiskra J, Limanova Z, Zima T and Potlukova E.

Thyroid in pregnancy: From physiology to screening.

Critical Reviews in Clinical Laboratory Sciences.

Feb 17;54(2):102–16.

Wiegratz I, Kutschera E, Lee JH, Moore C, Mellinger U,

Winkler UH, et al. Effect of four oral contraceptives

on thyroid hormones, adrenal and blood pressure

parameters. Contraception. 2003 May;67(5):361–6.

Starup J and Friis T. Thyroid function in oral contraception.

Acta Endocrinologica. 1967 Nov;56(3):525–32.

Hedayati M, Rajabi S and Nikzamir A. Papillary Thyroid

Cancer-Promoting Activities of Combined Oral

Contraceptive Components. Galen Med J.

;9:e1648.

Mannathazhathu AS, George PS, Sudhakaran S, Vasudevan

D, Krishna Km J, Booth C, et al. Reproductive factors

and thyroid cancer risk: Meta-analysis. Head Neck.

Dec;41(12):4199–208.

Cordina-Duverger E, Leux C, Neri M, Tcheandjieu C,

Guizard AV, Schvartz C, et al. Hormonal and

reproductive risk factors of papillary thyroid cancer:

A population-based case-control study in France.

Cancer Epidemiol. 2017 Jun;48:78–84.

Mitwally MFM. Fertility preservation and minimizing

reproductive damage in cancer survivors. Expert Rev

Anticancer Ther. 2007 Jul;7(7):989–1001.

Toro-Wills MF, Imitola-Madero A, Alvarez-Londoño A,

Hernández-Blanquisett A and Martínez-Ávila MC.

Thyroid cancer in women of reproductive age: Key

issues for the clinical team. Womens Health (Lond).

;18:17455057221136392.

Saputri Y, Nur IM and Damayanti MM. Karakteristik Pasien

dengan Nodul Tiroid di Rumah Sakit Al-Ihsan

Bandung. J Integr Kes Sains [Internet]. 2021 Jul 31

[cited 2024 Apr 7];3(2). Available from:

https://ejournal.unisba.ac.id/index.php/jiks/article/vi

ew/7412

Arrumugam K, Ekawati NP and Gotra IM. Characteristic of

thyroid carcinoma based on age, sex and histology

type at Sanglah General Hospital, Bali, Indonesia,

Intisari Sains Medis [Internet]. 2018 Dec 1

[cited 2024 Apr 7];9(3). Available from:

https://isainsmedis.id/index.php/ism/article/view/285

Asmelash D, Tesfa K and Biadgo B. Thyroid Dysfunction

and Cytological Patterns among Patients Requested

for Thyroid Function Test in an Endemic Goiter Area

of Gondar, North West Ethiopia. Int J Endocrinol.

;2019:9106767.

Bansode OM, Sarao MS and Cooper DB. Contraception. In:

StatPearls [Internet]. Treasure Island (FL): StatPearls

Publishing; 2024 [cited 2024 Apr 7]. Available from:

http://www.ncbi.nlm.nih.gov/books/NBK536949/

World Health Organization. Contraception [Internet]. 2024.

Available from: https://www.who.int/healthtopics/contraception#tab=tab_1

Nguyen N, Nguyen L, Nguyen H and Gallo MF. Correlates

of use of withdrawal for contraception among women

in Vietnam. BMC Womens Health. 2020 Apr

;20(1):87.

Costescu D, Chawla R, Hughes R, Teal S and Merz M.

Discontinuation rates of intrauterine contraception

due to unfavourable bleeding: a systematic review.

BMC Womens Health. 2022 Mar 21;22(1):82.

Iype E, Nair VR, Rajammal null. Laparoscopic removal of

displaced intra uterine devices. Asia Oceania J Obstet

Gynaecol. 1984 Jun;10(2):181–3.

Cartwright AF, Mackenzie ACL, Callahan RL,

Bahamondes MV and Dorflinger LJ. IUD selfremoval as self-care: Research is needed in low and middle-income countries. Front Glob Womens

Health. 2022;3:992639.

Badan Pusat Statistik Indonesia. Angka Penggunaan

Metode Kontrasepsi Jangka Panjang (MKJP) Cara

Modern, 2012-2017 [Internet]. 2024. Available from:

https://www.bps.go.id/id/statisticstable/2/MTM5NiMy/angka-penggunaan-metodekontrasepsi-jangka-panjang--mkjp--caramodern.html

Hussain I, Zulfiqar F, Li X, Ahmad S and Aljammal J.

Safety and Efficacy of Radiofrequency Ablation of

Thyroid Nodules-Expanding Treatment Options in

the United States. J Endocr Soc. 2021 Aug

;5(8):bvab110.

Cherian KE, Kapoor N, Paul TV and Asha HS. Functioning

Endocrine Tumors in Pregnancy: Diagnostic and

Therapeutic Challenges. Indian J Endocrinol Metab.

;25(4):299–304.

Harris ML, Feyissa TR, Bowden NA, Gemzell-Danielsson

K and Loxton D. Contraceptive use and contraceptive

counselling interventions for women of reproductive

age with cancer: a systematic review and metaanalysis. BMC Med. 2022 Dec 17;20(1):489.

27. Sutaryono S, Andasari SD and Kasjono HS. Diagnosis

and epidemiology of Coronavirus (COVID-19)

outbreak in Indonesia. J Teknol Lab. 2020 Jul

;9(1):49–57.

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