The Relationship between Antisperm Antibodies Prevalence and Genital Chlamydia trachomatis Infection in Women with Unexplained Infertility
Abstract
Chlamydia trachomatis infection is one of the most common sexually transmitted diseases and sperm-associated antibody could impair fertility through various mechanisms. Both factors could be correlated to affect the fertility status of women. A retrospective case-control studywas performed enrolling ninety (n=90) patients with primary or secondary infertility as the case group, in addition to another eighty (n=80) healthy women attending the family planning clinic to investigate the correlation between C. trachomatis past and current infections and antisperm antibodies (ASA) in women with unexplained infertility. The PCR prevalence of C. trachomatis didn't differ significantly among both groups (2.4 versus 1.6%, P=0.66).In contrast, significantly higher prevalence of anti- C. trachomatis specific IgG(39% versus 19%, P=0.87) antibodies were foundamong infertile women. ASA prevalence was significantly higher in infertile group (20 % versus 5%, P=0.04). The final study results have failed to find a positive correlation between current or past C. trachomatis infection and the level of antisperm antibodies level in women suffering of un-explained infertility. Anti-sperm antibodies were significantly higher in infertile women, but without a significant difference between the incidences of ASA in infertile women with past or current C.
trachomatis current infection (Afr J Reprod Health 2011; 15[3]:93-101).
Résumé
Les Rapports entre la prévalence des anti corps d’antispermes et l’infection de Chlamydia trachomatis génital chez les femmes atteintes d’une stérilité inexpliquée : L’infection de chlamydia trachomatis est une des maladies sexuellement transmissibles les plus communes et l’anticorps lié au sperme peut abimer la fertilité à travers divers mécanismes. Les deux facteurs peuvent être corrélés pour affecter l’état de fertilité des femmes. Une étude rétrospective basée sur l’étude de cas a été menée auprès des quatre-vingt –dix (n=90) patientes atteintes de la stérilité primaire et secondaire comme constituant le groupe de cas, y compris quatre-vingts (n=80) d’autres femmes en bonne santé qui fréquentaient la clinique de planification familiale afin d’étudier la corrélation entre l’ancien C. trachomatis et les infections actuelles et les anticorps antisperme (AAS) chez les femmes atteintes de la stérilité inexplicable. La prévalence de PCR par rapport à C. trachomatis n’a pas indiqué des différences remarquables parmi les deux groupes (2,4 contre 1,6%, Valeur de P= 0,06). Par contre, on a découvert des différences très remarquables par rapport aux anti-C . trachomatis de la spécificité 1gG (39% par opposition à 19%, valeur de P= 0,87) ont été trouvé chez les femmes stériles (20% par opposition à 5% P=0,04). Les résultats définitifs de l’étude n’a pas réussi à montrer une corrélation positive entre l’infection de C. trachomatis et le niveau d’anticorps d’antisperme chez les femmes stériles, mais sans une différence remarquable entre les incidences d’AAS chez les femmes stériles de C. trachomatis passé ou actuel (Afr J Reprod Health 2011; 15[3]:93-101).
Keywords: Antisperm-antibodies; Anti-C. trachomatis antibodies; un-explained infertility; pelvic inflammatory diseases
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