Maternal age and miscarriage: A unique association curve in Sudan

Bahaeldin A Hassan, Abdelmageed Elmugabil, Nadiah A Alhabrdi, Abdel B A Ahmed, Duria A Rayis, Ishag Adam


This study’s aim was to estimate the prevalence and maternal age and other risk factors of miscarriage among Sudanese women. A cross-sectional study was conducted at the Saad Abuelela Tertiary Hospital in Khartoum, Sudan, from February to December 2019. Sociodemographic, obstetric and clinical data were collected. A multivariate logistic regression analysis was performed. Four hundred thirteen (20.5%) women reported experiencing a miscarriage. Risk factors included older age, high parity, histories of caesarean delivery, and obesity. Logistic regression showed that the lowest risk for women aged less than 20 years (adjusted odds ratio [AOR], 0.33) or 20 to 24 years (AOR, 0.57), primiparas (AOR, 0.42) and women educated below the secondary level (AOR, 0.78). Unlike the global age-associated risk of miscarriage, the risk of miscarriage among Sudanese women follows a unique curve in relation to maternal age. Interestingly, the curve showed a lower risk for women less than 20 years and at 40 years. (Afr J Reprod Health 2022; 26 [7]: 15-21).

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Magnus MC, Wilcox AJ, Morken NH, Weinberg CR and

Håberg SE. Role of maternal age and pregnancy

history in risk of miscarriage: prospective register

based study. BMJ. 2019;364:l869. Published 2019

Mar 20. doi:10.1136/bmj.l869.

The Johns Hopkins Manual of Gynecology and Obstetrics

(Lippincott Manual Series): 9781605474335: Medicine & Health Science Books @ Accessed 12 Jul 2020.

Asiki G, Baisley K, Newton R, Marions L, Seeley J, Kamali

K and Smedman L. Adverse pregnancy outcomes in

rural Uganda (1996-2013): trends and associated

factors from serial cross sectional surveys. BMC

Pregnancy Childbirth. 2015;15:279. Published 2015

Oct 29. doi:10.1186/s12884-015-0708-8.

Cohain JS, Buxbaum RE and Mankuta D. Spontaneous first

trimester miscarriage rates per woman among parous

women with 1 or more pregnancies of 24 weeks or

more. BMC Pregnancy Childbirth. 2017;17(1):437.

Published 2017 Dec 22. doi:10.1186/s12884-017-


Regan L and Rai R. Epidemiology and the medical causes of

miscarriage. Baillieres Best Pract Res Clin Obstet

Gynaecol. 2000;14(5):839-854.


Dellicour S, Aol G, Ouma P, Yan N, Bigogo G, Hamel MJ,

Burton DC, Oneko M, Breiman RF, Slutsker L,

Feikin D, Kariuki S, Odhiambo F, Calip G, Stergachis A, Laserson KF, ter Kuile FO and Desai M. Weekly miscarriage rates in a community-based prospective cohort study in rural western Kenya. BMJ open, 2016,6(4), e011088.

Garrido-Gimenez, C and Alijotas-Reig J. Recurrent

miscarriage: causes, evaluation and

management. Postgraduate medical journal,

, 91(1073), 151–162.

Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G,

Howie SE and Horne AW. The role of infection in

miscarriage. Human reproduction update,2016, 22(1), 116–133.

Baudin M, Jumaa AM, Jomma H, Karsany MS, Bucht G,

Näslund J, Ahlm C, Evander M and Mohamed N. Association of Rift Valley fever virus infection with miscarriage in Sudanese women: a cross-sectional study. The Lancet. Global health, 2016,4(11), e864–e871.


Lean SC, Derricott H, Jones RL and Heazell A. Advanced

maternal age and adverse pregnancy outcomes: A

systematic review and meta-analysis. PloS

one, 2017,12(10), e0186287.

Moradinazar M, Najafi F, Nazar ZM, Hamzeh B, Pasdar Y

and Shakiba E. Lifetime Prevalence of Abortion and

Risk Factors in Women: Evidence from a Cohort Study. J Pregnancy. 2020;2020:4871494. Published 2020 Apr 27. doi:10.1155/2020/ 4871494.

Ota E, Haruna M, Suzuki M, Anh DD, Tho l, Tam NT,

Thiem VD, Anh NT, Isozaki M, Shibuya K, Ariyoshi

K, Murashima S, Moriuchi H and Yanai H. Maternal

body mass index and gestational weight gain and

their association with perinatal outcomes in Viet

Nam. Bulletin of the World Health Organization,2011, 89(2), 127–136.

Elghazali G, Adam I, Hamad A and El-Bashir MI.

Plasmodium falciparum infection during pregnancy

in an unstable transmission area in eastern Sudan. East Mediterr Health J. 2003;9(4):570-580.

Assefa N, Berhane Y and Worku A. Pregnancy rates and

pregnancy loss in Eastern Ethiopia. Acta Obstet Gynecol Scand. 2013;92(6):642-647. doi:10.1111/aogs.12097.

Esmeal MEA, Khalid NHM, Ilkheir RH and Fathelrahman

SA. Evaluation of First Trimester Miscarriage among

Sudanese Woman in Khartoum State Using

Ultrasonography. International Journal of Innovative Research in Medical Science,2019, 4(12), 647- 651.

Wilding M. Potential long-term risks associated with

maternal aging (the role of the mitochondria). Fertil Steril. 2015;103(6):1397-1401. doi:10.1016/j.fertnstert.2015.03.034.

Shirasuna K and Iwata H. Effect of aging on the female

reproductive function. Contracept Reprod Med. 2017;2:23. Published 2017 Oct 3. doi:10.1186/s40834-017-0050-9.

Belloc S, Cohen-Bacrie P, Benkhalifa M, Cohen-Bacrie M,

De Mouzon J, Hazout A and Ménézo Y. Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination. Reproductive biomedicine

online,2008, 17(3), 392–397.

Kirchengast S. Maternal age and pregnancy outcome--an

anthropological approach. Anthropol Anz.


Ciancimino L, Laganà AS, Chiofalo B, Granese R, Grasso

R and Triolo O. Would it be too late? A retrospective

case-control analysis to evaluate maternal-fetal

outcomes in advanced maternal age. Arch Gynecol

Obstet. 2014;290(6):1109-1114. doi:10.1007/s00404-014-3367-5.

Alsammani MA, Jafer AM, Khieri SA, Ali AO and

Shaaeldin MA. Effect of Grand Multiparity on

Pregnancy Outcomes in Women Under 35 Years of

Age: a Comparative Study. Med Arch. 2019;73(2):92-96. doi:10.5455/medarh.2019.73.92-

Sadiq AA, Poggensee G, Nguku P, Sabitu K, Abubakar A

and Puone T. Factors associated with adverse

pregnancy outcomes and perceptions of risk factors

among reproductive age women in Soba LGA,

Kaduna State 2013. Pan Afr Med J. 2016;25:111.

Published 2016 Oct 25. doi:10.11604/pamj.2016.25.111.8739.

Adjei G, Enuameh Y, Asante KP, Baiden FA, Nettey OE,

Abubakari S, Mahama E, Gyaase S and OwusuAgyei S. Predictors of abortions in Rural Ghana: a

cross-sectional study. BMC public

health, 2015;15:202. Published 2015 Feb 28.


Feodor Nilsson S, Andersen PK, Strandberg-Larsen K and

Nybo Andersen AM. Risk factors for miscarriage

from a prevention perspective: a nationwide followup study. BJOG. 2014;121(11):1375-1384.



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