Double Primary Malignancies in Patients with Gynaecological Cancers

A.S. Doh, VN.N Choundong

Abstract

The diagnosis of double primary cancers may be enhanced by greater clinical awareness and interest in such patients. A retrospective study involving the analysis of patient files and operative registers was carried out at the University Hospital Centre (UHC), Yaounde, Cameroon. Thirteen cases of double primary cancers, each involving at least one gynaecological malignancy, were managed over a nine year period at the University Hospital Centre. Nine different cancer associations were identified. There was a preponderance of cervical cancer, reflecting the high prevalence of this malignancy in our environment. Apart from the association between cervical and breast cancers that occurred in four patients, and cervical and large bowel cancers that occurred in two patients, no other preferential cancer association were observed. A patient with a gynaecological malignancy requires a thorough initial evaluation and life long follow-up in order to diagnose any possible second primary malignancy. (Afr I Rep rod Health 1997; 1(2) :96—102)

KEY Words: Multiple, primary, gynaecological cancers

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References

Adami HO, Bergkvist L, Krusemo U, Persson I. Breast cancer as a risk factor for other malignant diseases. A nationwide cohort study. JNCI;1984;73(5): 1049—55.

Bjorge T, Henning EM, Skare GB, Soreide 0, Thoresen S. Second primary cancers in patients with carcinoma in situ of the uterine cervix. mt I Cancer 1995;62:29—33.

Reimer RR, Hoover R, Fraumeni JF, Young RC. Second primary neoplasms following ovarian cancer. JNCI 1978;61(5):1195.

Warren 5, Gates 0. Multiple primary malignant tumours, survey of literature and statistical study. Am I Cancer 1932;16:1458—514.

Choo YC, Morley GW. Double primary epidermoid carcinoma of the vulva and cervix. Gynecol Oncol 1980;9:324—33.

Robinson E, Alder Z, Nasrallah S, et al. Clinical characteristics of patients with a second primary tumour in the endometrium or ovary. Eur I Gynecol Oncol 1995; 16(3): 195—8.

Takeda T, Sagae S, Koizumi M, et al. Multiple primary malignancies in patients with gynaecologic cancer. Intl Gynecol Cancer 1995; 5:34—9.

Hammond IG, Monaghan JM. Multicentric carcinoma of the female lower genital tract. Br I Obstet Gynecol 1983; 90: 557—6 1.

Arai T, Nakano T, Fukuhisa K, et al. Second cancer after radiation therapy for cancer of the uterine cervix. Cancer 199 l;67:398—405.

Doh AS, Ndzi J, Nasah BT. The pattern of gynaecological malignancies at the University Hospital Centre (CHU) Yaounde, Cameroon. CentAfrJMed988;345(l): 260—3.

Mould RF, Barret A. New primary cancers in patients originally presenting with cancer of the cervix. BrJ Obstet Gynecol 1976;83:81-5.

Peloquin A, Poljicak M, Falardeay M, et al. Survival of breast cancer patients with previous or subsequent neoplasms. Can I Surg 1992;35(5): 48 1-5.

Clarke EA, Kreigner N, Spengler RF. Second primary cancer following treatment for cervical cancer. Can Med AssocJ 1984;l31:553—6.

Storm HH. Second primary cancer after treatment for cervical cancer: late effects after radiotherapy. Cancer 1988:679—88.

Doh AS. Breast cancer pattern in sub-Saharan Africa. Paper presented to the Société française de senologie et de pathologie mammaire. Clermont-Ferrand, France: Société francaise de senologie et de pathologic mammaire, 1993.

Mbakop A, Essame-Oyono JL, Ngvangako MC. Epidemiologic actuelle des cancer au Cameroun. Paris: Bull Cancer, 1992;79( 11): 1101—4.

Rose PG, Herterick EE, Boutselis JG, Moeshberger M, Sachs L. Multiple primary gynaecologic neoplasms. Am I Obstet Gynecol 1987; 157:262—7.

Mitchell MF, Prasad CJ, Silva EG, Rutledge FN, McArthur MC, Crum CP. Second genital primary squamous neoplasms in vulvar carcinoma: viral and histopathologic correlates. Obstet Gynecol 1993;81:13—8.

Ohel G, Schwartz Z, Birkenfeld A, Anteby SO, Schenker JG. Second primary genital malignancies associated with endometrial cancer. Arch Gynecol 1996;239:75—85.

Schwartz Z, Ohel G, Birkenfeld A, Anteby SO, Schenker JG. Second primary malignancy in endometrial cancer patients. Gynecol Oncol 1985;22:40—5.

Morto RF, Villasanta U. New cancers arising in 1563 patients with carcinoma of the cervix treated by irradiation. Am I Obstet Gynecol 1973;115(4): 462—6.

Schottenfeld D, Berg I. Incidence of multiple primary cancers IV: cancers of the female breast and genital organs. I Nati Cancer Inst 197 1;46: 16 1—70.

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